- Mouse Anti-ZAP70 Antibody
- MyBioSource.com
- Pricing InfoSupplier PageView Company Product Page
- MBS4380715
- 0.02 mg (With BSA & Azide at 0.2mg/ml)
- Monoclonal
- Human. Others not known
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
- ELISA (EIA), Immunohistology (Formalin-Fixed)
- Mouse
- 70kDa
- ZAP70
- Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
- zeta chain of T cell receptor associated protein kinase 70
- STD, SRK, STCD, IMD48, ADMIO2, TZK, ZAP-70
- Unconjugated
- IgG2a kappa
- ZAP70/2046
Specifications/Features
ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene.ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well.Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis